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The 2010s introduced gene-expression analysis: data generated through the Broad Institute's Connectivity Map indicated that GHK exposure modulated expression of 4,192 of the 13,424 human genes assayed, with approximately equal up- and down-regulation across stress-response, inflammation, and tissue-repair pathways [2]

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For peripheral vascular disease, where reduced blood flow to the extremities causes pain and tissue damage, this collateral activation mechanism could theoretically provide meaningful benefit

"Until further investigations are done on liver stores and humans where this process is broken we can only go on our symptoms and what works for each individual to relieve these symptoms and to heal as much as possible